Why the study?
Do biomarkers of endothelial function and fibrinolysis predict progression to pre-diabetes more strongly in women than men?
Population
Participants free of type 2 diabetes and cardiovascular disease at baseline with normal fasting glucose
Comparison
Biomarkers of endothelial function… vs Men vs. Women and control subjects who did not…
Design
Cohort
Follow-up
6 years
Authors
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May indicate earlier endothelial risk activation in women; leaves open whether biomarkers enhance sex-specific pre-diabetes prediction.
Do biomarkers of endothelial function and fibrinolysis predict progression to pre-diabetes more strongly in women than men?
Women who progress from normoglycemia to pre-diabetes exhibit significantly greater endothelial dysfunction and pro-thrombotic biomarker profiles compared to men, suggesting cardiovascular risk mechanisms may activate earlier in women.
Donahue et al. (2007) studied this question.
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