What question did this study set out to answer?

This research aimed to evaluate the prognostic value of plasma CA125 in very elderly patients hospitalized for acute heart failure.

March 14, 2026Journal of Clinical MedicineOpen Access

Plasma CA125 as a Prognostic Marker in Very Elderly Patients Hospitalized for Acute Heart Failure

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Authors

JJJavier Jaramillo-HidalgoHospital Central de la Cruz Roja San José y Santa Adela MRMónica RamosHospital Central de la Cruz Roja San José y Santa Adela MQMaribel Quezada-FeijoóHospital Central de la Cruz Roja San José y Santa Adela

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Implication

Prospective observational study indicates elevated CA125 predicts mortality in very elderly patients hospitalized for heart failure, suggesting enhanced risk stratification.

Key Points

This research aimed to evaluate the prognostic value of plasma CA125 in very elderly patients hospitalized for acute heart failure.
Conducted a prospective observational study of patients aged ≥80 years with acute heart failure.
Measured CA125 and NT-proBNP within 24 hours of admission.
Assessed outcomes at 12 months using survival analyses.
Among 210 patients, 70 deaths (37.2%) and 68 heart failure hospital readmissions (36.1%) occurred during follow-up.
CA125 value ≥ 100 U/mL predicted higher mortality (HR 1.88) and composite endpoint (HR 1.54).
Functional dependence and frailty showed greater discriminative ability than biomarkers.

Cite This Study

Jaramillo-Hidalgo et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba2718185d8a39802d41 https://doi.org/10.3390/jcm15062156

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Implication

Prospective observational study indicates elevated CA125 predicts mortality in very elderly patients hospitalized for heart failure, suggesting enhanced risk stratification.

Plasma CA125 as a Prognostic Marker in Very Elderly Patients Hospitalized for Acute Heart Failure

Discussion

Member takes

Implication

Key Points

Cite This Study

Plasma CA125 as a Prognostic Marker in Very Elderly Patients Hospitalized for Acute Heart Failure

Discussion

Member takes

Implication

Key Points

Cite This Study

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