Carbohydrate antigen 125: an emerging prognostic risk factor in acute heart failure?
Key result
Elevated serum CA125 during acute heart failure hospitalization independently predicted 6-month mortality (HR 8.41; 95% CI 3.24-21.79 for the highest vs lowest quartile).
Why the study?
Do elevated circulating levels of carbohydrate antigen 125 (CA125) predict 6-month all-cause mortality in patients hospitalized for acute heart failure?
Population
529 consecutive patients with acute heart failure admitted to a single university centre in Spain.
Comparison
Measurement of serum carbohydrate antigen 125… vs Lower quartiles of CA125 (e.g., Quartile 1).
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
May support risk stratification in acute HF; leaves open prospective validation and therapeutic implications.
Study Design
Type
Cohort (n=529)
Multicenter
No
Structured PICO
Do elevated circulating levels of carbohydrate antigen 125 (CA125) predict 6-month all-cause mortality in patients hospitalized for acute heart failure?
P
Population
529 consecutive patients admitted with acute heart failure at a single center in Spain, followed for 6 months.
E
Exposure
Measurement of serum carbohydrate antigen 125 (CA125) during the early course of hospitalisation.
C
Comparator
Lower quartiles of CA125 (e.g., Quartile 1).
O
Outcome
6-month all-cause mortality.hard clinical
Main Result
Hazard Ratio: 8.41 (95% CI 3.24–21.79)
Absolute Event Rate: 26.5% vs 3.8%
p-value: p=<0.001
Elevated serum CA125 levels during early hospitalization for acute heart failure strongly and independently predict 6-month all-cause mortality in a dose-dependent manner.
Cite This Study
Núñez et al. (2006) conducted a cohort in acute heart failure (n=529). Carbohydrate antigen 125 (CA125) vs. First quartile of CA125 was evaluated on 6-month all-cause mortality (HR 8.41, 95% CI 3.24 to 21.79, p=<0.001). Elevated serum CA125 during acute heart failure hospitalization independently predicted 6-month mortality (HR 8.41; 95% CI 3.24-21.79 for the highest vs lowest quartile).