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March 15, 2026Journal of Personalized MedicineOpen Access

Modulation of Macrophage Inflammatory Responses by UDP-Glucuronosyltransferase-Mediated PGE2 Glucuronidation

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Authors

DLDahye LeeHCHee Young ChoSASangzin Ahn

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Overview

Demonstrates UGT influences pro-inflammatory cytokines in M1 and M2 macrophages, suggesting targeting UGT may alter immune responses.

Key Points

  • The aim is to investigate the role of UDP-glucuronosyltransferase in macrophage inflammatory responses and its expression in M1 and M2 macrophages.
  • THP-1 cells differentiated into macrophages were polarized into M1 and M2 phenotypes.
  • UGT expression assessed by RT-PCR and Western blot techniques.
  • UGT activity was measured using LC-MS/MS and ELISA for specific glucuronide metabolites.
  • M1 macrophages showed higher UGT1A1, UGT1A4, UGT1A5, UGT1A9, and UGT2B7 expression than M2 macrophages.
  • UGT activity led to increased production of estradiol-3-glucuronide and naloxone-3-glucuronide in M1.
  • Inhibition of UGTs by diclofenac reduced pro-inflammatory cytokines IL-1β and IL-6.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff4f83145bc643d1ba06https://doi.org/10.3390/jpm16030160
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