Why the study?
Does nitric oxide synthesis inhibition with L-NAME blunt the increase in digital pulse volume amplitude during reactive hyperemia in healthy subjects?
Does nitric oxide synthesis inhibition with L-NAME blunt the increase in digital pulse volume amplitude during reactive hyperemia in healthy subjects?
Nitric oxide plays a central role in the augmentation of digital pulse volume amplitude during reactive hyperemia, validating its use as a simple means of assessing endothelial function.
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NO inhibition blunts digital PVA-RH in healthy subjects; confirms mechanistic role but leaves open clinical validation as endothelial marker.
Nohria et al. (2006) studied this question.
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