April 14, 2006Journal of Applied Physiology
Role of nitric oxide in the regulation of digital pulse volume amplitude in humans
Why the study?
Does nitric oxide synthesis inhibition with L-NAME blunt the increase in digital pulse volume amplitude during reactive hyperemia in healthy subjects?
Population
Healthy subjects
Comparison
N(G)-nitro-L-arginine methyl ester (L-NAME) vs Saline and phenylephrine
Authors
Discussion
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Member takes
Implication
NO inhibition blunts digital PVA-RH in healthy subjects; confirms mechanistic role but leaves open clinical validation as endothelial marker.
Structured PICO
Does nitric oxide synthesis inhibition with L-NAME blunt the increase in digital pulse volume amplitude during reactive hyperemia in healthy subjects?
P
Population
Healthy subjects
I
Intervention
N(G)-nitro-L-arginine methyl ester (L-NAME)
C
Comparator
Saline and phenylephrine
O
Outcome
Change in digital pulse volume amplitude (PVA) at baseline and during reactive hyperemia (PVA-RH)surrogate
Nitric oxide plays a central role in the augmentation of digital pulse volume amplitude during reactive hyperemia, validating its use as a simple means of assessing endothelial function.
Cite This Study
Nohria et al. (2006) studied this question.