What question did this study set out to answer?

To assess whether nitric oxide regulates central hemodynamics, wave reflection, and pulse pressure amplification during light aerobic exercise.

February 20, 2008HypertensionOpen Access

Nitric Oxide Does Not Significantly Contribute to Changes in Pulse Pressure Amplification During Light Aerobic Exercise

View Full Paper

Ask AI

Bookmark

Why the study?

Does nitric oxide inhibition alter pulse pressure amplification and wave reflection during light aerobic exercise in healthy men?

Population

12 healthy men, mean age 29+/-1 years

Comparison

Intravenous infusion of N-monomethyl-l-arginine… vs Intravenous infusion of saline during cycle…

Design

Other

Authors

JSJames E. SharmanPreventive Cardiology CMCarmel M. McEnieryVascular Medicine RCRoss CampbellUniversity of Glasgow

Discussion

Member takes

Implication

No immediate clinical implications for exercise hemodynamics; leaves open primary mediators of arterial stiffness during light aerobic exercise.

Key Points

To assess whether nitric oxide regulates central hemodynamics, wave reflection, and pulse pressure amplification during light aerobic exercise.
Twelve healthy men (mean age 29±1 years) performed cycling exercise at 60% of their maximal heart rate.
Hemodynamics, augmentation index, and estimated aortic pulse wave velocity were evaluated via pulse wave analysis and bioimpedance across three intravenous infusion protocols: saline, N(G)-monomethyl-l-arginine, and noradrenaline.
At baseline, both N(G)-monomethyl-l-arginine and noradrenaline significantly increased mean arterial pressure (P<0.01) and augmentation index (P<0.01), and decreased the peripheral-to-central pulse pressure ratio (P<0.05).
During exercise, the peripheral-to-central pulse pressure ratio increased (P<0.001) while augmentation index and aortic pulse wave velocity decreased (both P<0.05), with no significant differences observed among the three infusions (P>0.50).

Structured PICO

Does nitric oxide inhibition alter pulse pressure amplification and wave reflection during light aerobic exercise in healthy men?

Population

12 healthy men, mean age 29+/-1 years

Intervention

Intravenous infusion of N(G)-monomethyl-l-arginine (a NO-synthase inhibitor) or noradrenaline (control vasoconstrictor) during cycle exercise at 60% of maximal heart rate

Comparator

Intravenous infusion of saline (control) during cycle exercise at 60% of maximal heart rate

Outcome

Pulse pressure (PP) amplification (ratio of peripheral to central PP) and wave reflection (augmentation index) during exercisesurrogate

Nitric oxide does not appear to be the sole contributor to systemic arterial stiffness or altered blood pressure amplification during light aerobic exercise in healthy men.

Limitations

Cannot rule out other vasodilator mechanisms having adjusted for NO blockade

Cite This Study

Sharman et al. (2008) studied this question.

synapsesocial.com/papers/6a8518dee7eca461fe84846a https://doi.org/10.1161/hypertensionaha.107.102558

View Full Paper

Ask AI

Bookmark

Implication

No immediate clinical implications for exercise hemodynamics; leaves open primary mediators of arterial stiffness during light aerobic exercise.

Nitric Oxide Does Not Significantly Contribute to Changes in Pulse Pressure Amplification During Light Aerobic Exercise

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Nitric Oxide Does Not Significantly Contribute to Changes in Pulse Pressure Amplification During Light Aerobic Exercise

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider