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This research evaluates long-term trends in hairy cell leukemia-related mortality in the U.S. from 1999 to 2023.

Long-Term Mortality Trends in Hairy Cell Leukemia in the U.S. (1999-2023)

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Comprehensive analysis reveals mortality patterns in hairy cell leukemia patients, indicating gender disparities and age-related trends.

This research evaluates long-term trends in hairy cell leukemia-related mortality in the U.S. from 1999 to 2023.
Analyzed CDC WONDER mortality records from 1999 to 2023 for hairy cell leukemia.
Calculated age-adjusted mortality rates (AAMR) and stratified data by demographics.
Utilized joinpoint regression to identify annual percent changes and inflection points.
Total of 4,496 HCL-related deaths from 1999 to 2023.
Overall AAMR declined from 0.056 in 1999 to 0.040 in 2018, then increased to 0.043 in 2023.
Significant increase in AAMR for males observed since 2015, with recent rates rising to 0.096 in 2023.

Sorathia et al. (2026) studied this question.

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