Why the study?
Does acute systemic inflammation induced by S typhi vaccine impair endothelium-dependent dilatation in humans?
Does acute systemic inflammation induced by S typhi vaccine impair endothelium-dependent dilatation in humans?
Acute systemic inflammation causes temporary but profound arterial endothelial dysfunction, providing a potential mechanism for the increased cardiovascular risk associated with infection.
Acute inflammation may impair endothelial function; leaves open whether this drives infection-related cardiovascular events in patients.
S typhi vaccine generates a mild inflammatory reaction associated with temporary but profound dysfunction of the arterial endothelium in both resistance and conduit vessels to both physical and pharmacological dilator stimuli. This finding might explain the association between infection and inflammation and the enhanced risk of an acute cardiovascular event.
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Hingorani et al. (2000) studied this question.
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