Why the study?
Does low-renin hypertension with relative aldosterone excess impair nitric oxide-mediated vasodilation?
Does low-renin hypertension with relative aldosterone excess impair nitric oxide-mediated vasodilation?
Low-renin hypertension is associated with marked impairment of nitric oxide-mediated vasodilation, which may contribute to the increased risk of adverse cardiovascular outcomes in these patients.
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Low-renin hypertension may impair NO-mediated vasodilation; leaves open contribution to CV risk and therapeutic implications.
Duffy et al. (2005) studied this question.
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