Demonstrates that during L-NAME-induced hypertension with suppressed hypertrophy, the heart maintains systolic performance via LV remodeling and enhanced calcium-dependent contractility.
May guide mechanistic research on calcium-dependent adaptation in pressure overload; leaves open human translation.
When the expected compensatory hypertrophic response is suppressed during L-NAME-induced hypertension, severe chronic pressure overload is associated with a successful adaptation to maintain systolic performance; this adaptation depends on both LV remodeling and enhanced contractility in response to calcium.
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Bartúnek et al. (2000) studied this question.
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