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March 3, 2020International Journal of Molecular MedicineOpen Access

Proteomics analysis of potential serum biomarkers for insulin resistance in patients with polycystic ovary syndrome

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Why the study?

The study was conducted to identify potential serum biomarkers for insulin resistance in patients with polycystic ovary syndrome.

Are there differentially expressed serum proteins that can serve as biomarkers for insulin resistance in patients with PCOS?

Population

218 PCOS patients aged 18 to 35 years

Comparison

PCOS with insulin resistance vs PCOS without insulin resistance

Authors

LLLi LiWuhan UniversityJZJing ZhangQinghai UniversityJZJing ZengFujian Medical University

Discussion

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Implication

APOC3 association with HOMA-IR in PCOS is hypothesis-generating; leaves open biomarker validation in prospective studies before any clinical use.

Structured PICO

Are there differentially expressed serum proteins that can serve as biomarkers for insulin resistance in patients with PCOS?

P
Population
218 patients aged 18 to 35 years with polycystic ovary syndrome (PCOS), divided into insulin resistance (PCOS-IR) and non-insulin resistance (PCOS-NIR) groups.
C
Comparator
PCOS patients without insulin resistance (PCOS-NIR)
O
Outcome
Differentially expressed serum proteins between PCOS-IR and PCOS-NIR groupssurrogate

APOC3 is a potential diagnostic serum biomarker for insulin resistance in patients with polycystic ovary syndrome.

Cite This Study

Li et al. (2020) studied this question.

synapsesocial.com/papers/69d575a85f8349d3f7ad50f6https://doi.org/10.3892/ijmm.2020.4522
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Also Consider

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  3. 3Combination of Diane-35 and Metformin to Treat Early Endometrial Carcinoma in PCOS Women with Insulin Resistance2014 · 61 citations
  4. 4Correlation of Hyperandrogenism with Hyperinsulinism in Polycystic Ovarian Disease*1980 · 922 citations
  5. 5Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance2011 · 135 citations