August 26, 2023European Heart Journal70 citationsOpen Access
View Full PaperUpgrade of right ventricular pacing to cardiac resynchronization therapy in heart failure: a randomized trial
Structured PICO
Does upgrade to CRT-D reduce the combined risk of all-cause mortality, heart failure hospitalization, or absence of reverse remodelling in pacemaker or ICD patients with significant RVP burden and reduced ejection fraction?
P
Population
Pacemaker or ICD patients with significant right ventricular pacing (RVP) burden and reduced ejection fraction
I
Intervention
Upgrade to cardiac resynchronization therapy with defibrillator (CRT-D)
C
Comparator
ICD therapy
O
Outcome
Combined risk of all-cause mortality, heart failure hospitalization, or absence of reverse remodellingcomposite
Upgrading to CRT-D improves clinical and echocardiographic outcomes in patients with reduced ejection fraction and high right ventricular pacing burden compared to ICD therapy alone.
Abstract
In pacemaker or ICD patients with significant RVP burden and reduced ejection fraction, upgrade to CRT-D compared with ICD therapy reduced the combined risk of all-cause mortality, heart failure hospitalization, or absence of reverse remodelling.