Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

Alkın Kumral; Murat Giriş; Merva Soluk Tekkeşin; Vakur Olgaç; Semra Doğru‐Abbasoğlu; Ümit Türkoğlu; Müjdat Uysal

doi:10.1177/0960327115597468

July 29, 2015Human & Experimental ToxicologyOpen Access

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

View Full Paper

Ask AI

Bookmark

Share

Key Points

To evaluate whether carnosine alone or combined with vitamin E protects against doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats.
Treated a rat model of doxorubicin-induced toxicity with carnosine alone and carnosine combined with vitamin E.
Evaluated therapeutic outcomes through cardiac, hepatic, and renal biomarkers, oxidative stress parameters, and histopathologic tissue examination.
Carnosine alone, and especially when combined with vitamin E, mitigated doxorubicin-induced organ toxicity across heart, liver, and kidney tissues.
Therapy restored balance to the prooxidant state, improved biochemical markers of organ function, and ameliorated histopathologic tissue damage.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Demonstrates that carnosine with vitamin E reduces multi-organ damage in rats, suggesting protection against doxorubicin-induced toxicity.

Abstract

Our results may indicate that CAR alone, especially in combination with Vit E, protect against DOX-induced toxicity in heart, liver, and kidney tissues of rats. This was evidenced by improved cardiac, hepatic, and renal markers and restoration of the prooxidant state and amelioration of histopathologic changes.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kumral et al. (2015) studied this question.

synapsesocial.com/papers/69e5c3585cb6e92637e7062d https://doi.org/10.1177/0960327115597468

View Full Paper

Ask AI

Bookmark

Share

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading