What question did this study set out to answer?

The aim is to determine the correlation between amniotic fluid and maternal plasma levels of specific hormones during normal and pathological pregnancies.

April 27, 2026Open Access

Lack of correlation between amniotic fluid and maternal plasma contents of beta-endorphin, beta-lipotropin, and adrenocorticotropic hormone in normal and pathologic pregnancies.

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Authors

AGAr GenazzaniUniversity of Pisa FPF. Petraglia DPD. Parrini

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Implication

Study investigates hormonal levels in amniotic fluid and plasma of pregnant women, revealing no correlation among groups.

Key Points

The aim is to determine the correlation between amniotic fluid and maternal plasma levels of specific hormones during normal and pathological pregnancies.
Analyzed concentrations of beta-endorphin, beta-lipotropin, and ACTH in amniotic fluid and plasma of 40 healthy and 20 pathologic pregnant women.
Used silicic acid extraction followed by Sephadex G-75 column chromatography for sample processing.
Measured hormone levels using specific radioimmunoassays.
Beta-endorphin levels in amniotic fluid were highest in the first trimester (173 +/- 30 fmol/ml) and decreased significantly in subsequent trimesters.
Plasma levels of beta-endorphin showed a progressive increase from the first trimester to term.
ACTH levels in amniotic fluid decreased in the second trimester but rose again by the third trimester, while plasma levels significantly decreased at term to 8.9 +/- 1.4 fmol/ml.

Cite This Study

Genazzani et al. (1984) studied this question.

synapsesocial.com/papers/69eefdb5fede9185760d4730 https://doi.org/10.1016/s0002-9378(84)80176-1

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Lack of correlation between amniotic fluid and maternal plasma contents of beta-endorphin, beta-lipotropin, and adrenocorticotropic hormone in normal and pathologic pregnancies.

Discussion

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Implication

Key Points

Cite This Study

Lack of correlation between amniotic fluid and maternal plasma contents of beta-endorphin, beta-lipotropin, and adrenocorticotropic hormone in normal and pathologic pregnancies.

Discussion

Member takes

Implication

Key Points

Cite This Study

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