Key result
High BNP and IL-6 levels independently predict mortality in severe CHF following optimized treatment.
Why the study?
Neurohumoral and immune activation play an important role in CHF pathophysiology, but the prognostic value of serial changes in these factors remained unknown.
Population
102 consecutive patients with severe CHF (NYHA class III to IV) on admission
Design
Prospective cohort study with treating physicians blinded to neurohumoral factors
Follow-up
Mean 807 days
Authors
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May aid risk stratification in severe CHF using 3-month BNP/IL-6; leaves open guided therapy benefits pending randomized trials.
Cohort (n=102)
Blinded to biomarker levels
No
Maeda et al. (2000) conducted a cohort in Severe congestive heart failure (NYHA class III to IV) (n=102). Optimized standard treatment for CHF was evaluated on Mortality (Cardiac death). High plasma BNP and IL-6 levels three months after optimized treatment independently predicted mortality in severe CHF, with cardiac death occurring in 26 of 102 patients over a mean 807 days.
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