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June 14, 1999Archives of Internal Medicine

Profile for Estimating Risk of Heart Failure

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Why the study?

Does a multivariate risk profile accurately estimate the risk of developing heart failure in predisposed individuals?

Population

Persons predisposed to heart failure by coronary disease, hypertension, or valvular heart disease, with 486…

Design

Cohort

Follow-up

38 years

Authors

WKW B KannelGeneral / Preventive / LipidsRDRalph B. D’AgostinoWake Forest UniversityHSHalit SilbershatzGeneral / Preventive / Lipids

Discussion

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Member takes

Overview

May help target prevention to high-risk groups; leaves open prospective validation of risk-guided strategies.

Structured PICO

Does a multivariate risk profile accurately estimate the risk of developing heart failure in predisposed individuals?

P
Population
Persons predisposed to heart failure by coronary disease, hypertension, or valvular heart disease, with 486 heart failure cases observed over 38 years of follow-up.
I
Intervention
Multivariate risk profile using age, electrocardiographic left ventricular hypertrophy, cardiomegaly on chest x-ray, heart rate, systolic blood pressure, vital capacity, diabetes mellitus, evidence of myocardial infarction, and valvular disease or hypertension.
O
Outcome
Development of heart failure (4-year probability)hard clinical

A multivariate risk profile using routine clinical variables can effectively identify individuals at high risk for developing heart failure, with the majority of events occurring in the top quintile of risk.

Cite This Study

Kannel et al. (1999) studied this question.

synapsesocial.com/papers/69f53e9de0fbb6efbd20372fhttps://doi.org/10.1001/archinte.159.11.1197

Topics

Heart failureHFrEF treatmentHypertension managementValvular heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Captopril on Progressive Ventricular Dilatation after Anterior Myocardial Infarction1988 · 1,103 citations
  2. 2The Natural History of Congestive Heart Failure: The Framingham Study1971 · 3,492 citations
  3. 3Survival after the onset of congestive heart failure in Framingham Heart Study subjects.1993 · 1,873 citations
  4. 4Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions1992 · 3,758 citations
  5. 5Epidemiological Approaches to Heart Disease: The Framingham Study1951 · 2,186 citations