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January 1, 1992Archives of Internal Medicine

Serum Cholesterol, Blood Pressure, Cigarette Smoking, and Death From Coronary Heart Disease Overall Findings and Differences by Age for 316099 White Men

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Why the study?

Do blood pressure, serum cholesterol, and cigarette smoking predict death from coronary heart disease in white men across different age groups?

Population

316,099 white men screened for the Multiple Risk Factor Intervention Trial (MRFIT)

Design

Cohort

Follow-up

average 12 years

Authors

JNJames D. NeatonPreventive Cardiology

Discussion

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Implication

Extreme combined risk factor burden signals very high CHD mortality; leaves open whether control alters outcomes in contemporary cohorts.

Key Points

  • To evaluate the combined impact of blood pressure, serum cholesterol levels, and cigarette smoking on coronary heart disease mortality and examine how these risks vary across age groups.
  • Analyzed baseline screening data and mortality outcomes for 316,099 men screened for the Multiple Risk Factor Intervention Trial (MRFIT).
  • Followed participant vital status over an average follow-up period of 12 years to ascertain coronary heart disease mortality.
  • Identified 6,327 coronary heart disease deaths, demonstrating strong graded relationships with serum cholesterol (>4.65 mmol/L or 180 mg/dL), systolic blood pressure (>110 mm Hg), and diastolic blood pressure (>70 mm Hg).
  • Smokers with both systolic blood pressure and serum cholesterol in the highest quintiles had coronary heart disease death rates approximately 20 times greater than nonsmoking men in the lowest quintiles.
  • Systolic blood pressure, diastolic blood pressure, serum cholesterol, and cigarettes smoked per day significantly predicted coronary heart disease death across all age groups, with systolic pressure acting as a stronger predictor than diastolic pressure.

Structured PICO

Do blood pressure, serum cholesterol, and cigarette smoking predict death from coronary heart disease in white men across different age groups?

P
Population
316,099 white men screened for the Multiple Risk Factor Intervention Trial (MRFIT)
O
Outcome
Death from coronary heart disease (CHD)hard clinical

Cite This Study

James D. Neaton (1992) studied this question.

synapsesocial.com/papers/69f53e9de0fbb6efbd20373dhttps://doi.org/10.1001/archinte.1992.00400130082009
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