Why the study?
What is the natural history, rate of progression, and prognosis of acquired aortic stenosis?
Population
Patients with acquired aortic stenosis, including 142 patients with mild stenosis and 55 patients with…
Design
Cohort
Follow-up
Up to 25 years
Authors
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Supports counseling against surgery refusal in severe symptomatic aortic stenosis; extends symptom-specific survival benchmarks in observational cohorts.
What is the natural history, rate of progression, and prognosis of acquired aortic stenosis?
This study demonstrates that while mild aortic stenosis progresses slowly, severe symptomatic aortic stenosis has a dismal prognosis without surgical intervention, with survival heavily dependent on the specific symptoms present.
Horstkotte et al. (1988) studied this question.