What is the clinical evidence from this study?

Study design: Cohort. Population: Valvular aortic stenosis (n=26). Primary outcome: Change in aortic valve area.

What question did this study set out to answer?

To assess the long-term rate of progression of valvular aortic stenosis and identify clinical predictors of worsening severity in patients initially managed without surgery.

January 12, 1983Acta Medica Scandinavica

Rate of Progression of Severity of Valvular Aortic Stenosis

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Key result

Valvular aortic stenosis progressed slowly over an average of 9 years, with a mean annual decrease in valve area of about 0.1 cm2 in 10 patients and less in the remaining patients.

Population

26 patients with valvular aortic stenosis initially considered too mild for surgical treatment

Design

Cohort

Follow-up

average 9 years

Authors

RJRune JonassonKarolinska University Hospital BJBengt JönssonStockholm School of Economics RNRolf NordlanderÖrebro University

Discussion

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Implication

May support periodic monitoring in aortic stenosis; leaves open optimal surveillance intervals for moderate cases.

Key Points

To assess the long-term rate of progression of valvular aortic stenosis and identify clinical predictors of worsening severity in patients initially managed without surgery.
Followed 26 patients with mild valvular aortic stenosis over an average follow-up duration of 9 years.
Evaluated hemodynamic changes via valve area measurements alongside chest X-ray calcification assessments and exercise electrocardiography.
Aortic valve area decreased from a mean of 1.2 cm² (range 0.7–1.9 cm²) to 0.9 cm² (range 0.3–2.0 cm²), with an annual decline of approximately 0.1 cm² in 10 patients and less in the remaining 16.
Advanced age and reduced physical working capacity at baseline were associated with faster progression, though rapid worsening remained unpredictable.
A clinical combination of valve calcification, low physical working capacity, and post-exercise V6 T-wave abnormalities was present in 100% of severe stenosis cases (<<0.6 cm²) and 10% of mild cases (>>1.0 cm²).

Study Design

Type

Cohort (n=26)

Structured PICO

Population

26 patients with valvular aortic stenosis initially considered too mild for surgical treatment

Outcome

Change in valve area over timesurrogate

Valvular aortic stenosis generally progresses slowly in adults, but moderate cases can become severe within a few years, highlighting the need for regular follow-up.

Cite This Study

Jonasson et al. (1983) conducted a cohort in Valvular aortic stenosis (n=26). Valvular aortic stenosis progressed slowly over an average of 9 years, with a mean annual decrease in valve area of about 0.1 cm2 in 10 patients and less in the remaining patients.

synapsesocial.com/papers/6a1056d0e1a472cb5efcbafe https://doi.org/10.1111/j.0954-6820.1983.tb03689.x

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Rate of Progression of Severity of Valvular Aortic Stenosis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Rate of Progression of Severity of Valvular Aortic Stenosis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider