What question did this study set out to answer?

This study aims to determine if urinary albumin-to-creatinine ratio is an independent predictor of ischemic heart disease.

August 1, 1999Arteriosclerosis Thrombosis and Vascular Biology

Urinary Albumin Excretion

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Why the study?

Does microalbuminuria predict ischemic heart disease in a population-based cohort without baseline IHD, renal disease, or diabetes?

Key Points

This study aims to determine if urinary albumin-to-creatinine ratio is an independent predictor of ischemic heart disease.
Prospective analysis of 2085 participants without ischemic heart disease or diabetes
Urinary albumin and creatinine levels were measured in 1983
Participants were followed until death or 1993 to assess ischemic heart disease incidence
79 individuals developed ischemic heart disease during 21,130 person-years of follow-up
Relative risk of ischemic heart disease with microalbuminuria was 2.3 (95% CI, 1.3 to 3.9, P=0.002)
10-year disease-free survival decreased from 97% to 91% with microalbuminuria (P<0.0001)

Structured PICO

Does microalbuminuria predict ischemic heart disease in a population-based cohort without baseline IHD, renal disease, or diabetes?

Population

2085 consecutive participants without ischemic heart disease, renal disease, urinary tract infection, or diabetes mellitus

Intervention

Presence of microalbuminuria (urinary albumin-to-creatinine ratio >90 percentile, >0.65 mg/mmol)

Comparator

Absence of microalbuminuria

Outcome

Ischemic heart disease (IHD) defined as a hospital discharge diagnosis or cause of death (ICD-8 410 to 414)hard clinical

Discussion

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Implication

Microalbuminuria is an independent predictor of ischemic heart disease in individuals without baseline IHD or diabetes, and it amplifies the risk of conventional atherosclerotic risk factors.

Cite This Study

Borch‐Johnsen et al. (1999) studied this question.

synapsesocial.com/papers/69f7e3456d1e8212df5a2d26 https://doi.org/10.1161/01.atv.19.8.1992

Topics

Hypertension management Women and heart disease

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Implication

Microalbuminuria is an independent predictor of ischemic heart disease in individuals without baseline IHD or diabetes, and it amplifies the risk of conventional atherosclerotic risk factors.

Urinary Albumin Excretion

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Urinary Albumin Excretion

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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