March 1, 2000Pacing and Clinical Electrophysiology
ST Segment and T Wave Alternans in a Patient with Brugada Syndrome
Population
1 patient with Brugada syndrome
Design
Case_report
Authors
Discussion
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Member takes
Implication
Caution warranted in interpreting single-case provocations; leaves open whether pacing or drugs aid Brugada risk stratification.
Key Points
- This analysis aims to explore the cardiac electrical activity changes in a patient with Brugada syndrome.
- Described case of a patient with Brugada syndrome and observed ST-segment elevation in leads V1 and V2.
- Atrial pacing and intravenous administration of propranolol or cibenzoline were performed.
- Illustrated the cellular mechanism behind observed T wave alternans.
- Significant T wave alternans with a 2:1 appearance of terminal negative T wave was observed.
- J point and ST-segment elevation were augmented by both atrial pacing and drug administration.
- The presence of T wave alternans occurred with and without atrial pacing following cibenzoline administration.
Structured PICO
P
Population
1 patient with Brugada syndrome
I
Intervention
Atrial pacing and intravenous administration of propranolol or cibenzoline
O
Outcome
Observation of J point and ST-segment elevation, and T wave alternanssurrogate
This case report demonstrates the augmentation of ST-segment elevation and induction of T wave alternans by atrial pacing and pharmacological provocation in a patient with Brugada syndrome.
Cite This Study
Tada et al. (2000) studied this question.