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September 27, 2013Journal of Cardiovascular PharmacologyOpen Access

Cardiac Titin and Heart Disease

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Population

Patients with heart disease, specifically dilated cardiomyopathy, heart failure with preserved ejection…

Design

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Authors

MLMartin M. LeWinterHeart Failure & TransplantHGHenk GranzierHeart Failure & Transplant

Discussion

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Implication

Titin represents a potential novel therapeutic target; leaves open clinical translation in DCM and HFpEF.

Structured PICO

P
Population
Patients with heart disease, specifically dilated cardiomyopathy (DCM), heart failure with preserved ejection fraction (HFpEF), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular dysplasia (ARVD)

Titin plays a crucial role in myocardial passive stiffness and is a major disease gene in inherited cardiomyopathies, presenting a potential novel therapeutic target.

Cite This Study

LeWinter et al. (2013) studied this question.

synapsesocial.com/papers/69fe79e2d8476229fea35a83https://doi.org/10.1097/fjc.0000000000000007

Topics

Heart failureHFrEF treatmentHypertrophic cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation2013 · 188 citations
  2. 2Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy2001 · 693 citations
  3. 3Thin Filament-Based Modulation of Contractile Performance in Human Heart Failure2004 · 71 citations
  4. 4The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line.1988 · 626 citations
  5. 5Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction2013 · 1,155 citations