What question did this study set out to answer?

To determine the relationship between adiposity metrics and biomarkers of inflammation and oxidative stress in patients with moderate to severe chronic kidney disease compared to healthy controls.

February 7, 2008Journal of the American Society of Nephrology

Oxidative Stress and Inflammation Are Associated with Adiposity in Moderate to Severe CKD

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Authors

LRLuis F. RamosVanderbilt University Medical Center ASAyumi ShintaniOsaka Gakuin University TİT. Alp İkizlerTufts University

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Implication

Observational study reveals increased adiposity correlates with elevated oxidative stress and inflammation in moderate to severe CKD, suggesting weight loss may lower cardiovascular risk.

Key Points

To determine the relationship between adiposity metrics and biomarkers of inflammation and oxidative stress in patients with moderate to severe chronic kidney disease compared to healthy controls.
Cross-sectional evaluation of 184 patients with stage III to IV chronic kidney disease and 43 healthy controls.
Assessed body mass index (BMI) and body fat percentage alongside inflammatory markers (C-reactive protein) and oxidative stress biomarkers (F(2)-isoprostanes, protein thiols).
Multivariable linear regression models adjusted for age, sex, race, hypertension, diabetes mellitus, smoking history, eGFR, total cholesterol, serum albumin, and study site.
Patients with CKD had 62% higher F(2)-isoprostanes, 7% lower protein thiols, and 150% higher C-reactive protein levels relative to healthy controls (all unadjusted P < 0.001).
In adjusted multivariable linear regression, both BMI and body fat percentage positively correlated with F(2)-isoprostanes and C-reactive protein, and negatively correlated with protein thiols among CKD patients.

Cite This Study

Ramos et al. (2008) studied this question.

synapsesocial.com/papers/6a00a034e4618ba4162db4a8 https://doi.org/10.1681/asn.2007030355

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Implication

Observational study reveals increased adiposity correlates with elevated oxidative stress and inflammation in moderate to severe CKD, suggesting weight loss may lower cardiovascular risk.

Oxidative Stress and Inflammation Are Associated with Adiposity in Moderate to Severe CKD

Discussion

Member takes

Implication

Key Points

Cite This Study

Oxidative Stress and Inflammation Are Associated with Adiposity in Moderate to Severe CKD

Discussion

Member takes

Implication

Key Points

Cite This Study

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