Body mass index was an independent predictor of epicardial fat thickness (B 0.371) in pre-dialysis diabetic and non-diabetic chronic kidney disease patients.
Cross-Sectional
Do pre-dialysis CKD patients (diabetic and non-diabetic) have increased perirenal and epicardial fat thickness, oxidative stress, and inflammation compared to healthy controls?
Pre-dialysis CKD patients, particularly those with diabetes, exhibit increased visceral adiposity (perirenal and epicardial fat) which is associated with higher oxidative stress and inflammation.
Effect estimate: B 0.371 (95% CI 0.169 to 0.573)
p-value: p=0.001
Aim and objectives This study aimed to evaluate perirenal and epicardial fat thickness and examine their associations with oxidative stress, inflammation, and metabolic markers in pre-dialysis CKD patients (diabetic and non-diabetic) compared with healthy controls. Material and methods This cross-sectional study included 90 participants (30 diabetic CKD, 30 non-diabetic CKD, and 30 controls). Perirenal fat thickness was assessed by ultrasonography and epicardial fat thickness by echocardiography. Biochemical parameters including renal function, lipid profile, hs-CRP, malondialdehyde (MDA), and ferric reducing antioxidant power (FRAP) were measured. Statistical analysis was performed using parametric or non-parametric tests based on data distribution, with multivariate regression adjusting for age, sex, and BMI. Results DKD patients had significantly higher perirenal (32.1 ± 5.0 mm) and epicardial (8.72 ± 1.89 mm) fat thickness compared to non-DKD patients and controls. DKD patients also exhibited increased oxidative stress (MDA 4.65 ± 3.39 µmol/L) and decreased antioxidant capacity (FRAP 0.25 ± 0.16 mmol/L). The inflammatory marker hs-CRP was significantly elevated in DKD patients 8.53 (12.64) mg/L. No significant differences were observed in lipid profiles or atherogenic indices between groups; however, visceral adiposity showed significant positive correlations with atherogenic indices. Conclusion Pre-dialysis CKD patients, particularly those with diabetes, exhibit increased visceral adiposity along with higher oxidative stress and inflammation. Although atherogenic indices were not significantly different between groups, their association with visceral fat suggests a potential role of regional adiposity as a marker of metabolic risk; however, longitudinal studies are required to establish the prognostic significance.
Kamat et al. (Mon,) conducted a cross-sectional in Pre-dialysis chronic kidney disease (CKD). Body Mass Index (BMI) was evaluated on Epicardial Fat Thickness (B 0.371, 95% CI 0.169 to 0.573, p=0.001). Body mass index was an independent predictor of epicardial fat thickness (B 0.371) in pre-dialysis diabetic and non-diabetic chronic kidney disease patients.