Why the study?
Perirenal fat may exert direct lipotoxic effects on renal function and intrarenal hydrostatic pressure, but its association with cardiovascular risk factors across stages of chronic kidney disease was unexplored.
Is perirenal fat thickness associated with metabolic risk factors and disease severity in patients with chronic kidney disease?
Population
103 patients with CKD stages 1 to 5
Comparison
Perirenal fat thickness across CKD stages and metabolic risk factor levels
Design
Cross-sectional study
Key result
In patients with chronic kidney disease, perirenal fat thickness was significantly greater in those with impaired fasting glucose (1.10 cm vs 0.85 cm) and elevated triglycerides (1.09 cm vs 0.86 cm).
Authors
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Should not yet change CKD practice; hypothesis-generating for perirenal fat as metabolic marker, needs longitudinal validation.
Cohort (n=103)
No
Is perirenal fat thickness associated with metabolic risk factors and disease severity in patients with chronic kidney disease?
Absolute Event Rate: 1.1% vs 0.85%
p-value: p=<0.01
Increased perirenal fat thickness is associated with metabolic risk factors such as impaired fasting glucose and hypertriglyceridemia in patients with chronic kidney disease.
D’Marco et al. (2019) conducted a cohort in Chronic kidney disease (n=103). Impaired fasting glucose (≥ 100 mg/dL) vs. Normal fasting glucose (< 100 mg/dL) was evaluated on Perirenal fat thickness (cm) (p=<0.01). In patients with chronic kidney disease, perirenal fat thickness was significantly greater in those with impaired fasting glucose (1.10 cm vs 0.85 cm) and elevated triglycerides (1.09 cm vs 0.86 cm).