Key result
In patients with chronic kidney disease, perirenal fat thickness was significantly greater in those with impaired fasting glucose (1.10 cm vs 0.85 cm) and elevated triglycerides (1.09 cm vs 0.86 cm).
Why the study?
Perirenal fat may exert direct lipotoxic effects on renal function and intrarenal hydrostatic pressure, but its association with cardiovascular risk factors across stages of chronic kidney disease was unexplored.
Is perirenal fat thickness associated with metabolic risk factors and disease severity in patients with chronic kidney disease?
Cohort (n=103)
No
Is perirenal fat thickness associated with metabolic risk factors and disease severity in patients with chronic kidney disease?
Increased perirenal fat thickness is associated with metabolic risk factors such as impaired fasting glucose and hypertriglyceridemia in patients with chronic kidney disease.
Answers are grounded in this paper and cite their sources.
Should not yet change CKD practice; hypothesis-generating for perirenal fat as metabolic marker, needs longitudinal validation.
Background: Adipose tissue accumulation in specific body compartments has been associated with diabetes, hypertension and dyslipidemia. Perirenal fat (PRF) may lead to have direct lipotoxic effects on renal function and intrarenal hydrostatic pressure. This study was undertaken to explore the association of PRF with cardiovascular risk factors and different stages of chronic kidney disease (CKD). Methods: We studied 103 patients with CKD of different stages (1 to 5). PRF was measured by B-mode renal ultrasonography in the distal third between the cortex and the hepatic border and/or spleen. Results: The PRF thickness was greater in CKD patients with impaired fasting glucose than in those with normal glucose levels (1.10 0.40 cm vs. 0.85 0.39 cm, P < 0.01). Patients in CKD stages 4 and 5 (glomerular filtration rate [GFR] < 30 mL/min/1.73 m 2 ) had the highest PRF thickness. Serum triglyceride levels correlated positively with the PRF thickness; the PRF thickness was greater in patients with triglyceride levels 150 mg/dL (1.09 0.40 cm vs. 0.86 0.36 cm, P < 0.01). In patients with a GFR < 60 mL/min/1.73 m 2 , uric acid levels correlated positively with the PRF thickness (P < 0.05).
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D’Marco et al. (2019) conducted a cohort in Chronic kidney disease (n=103). Impaired fasting glucose (≥ 100 mg/dL) vs. Normal fasting glucose (< 100 mg/dL) was evaluated on Perirenal fat thickness (cm) (p=<0.01). In patients with chronic kidney disease, perirenal fat thickness was significantly greater in those with impaired fasting glucose (1.10 cm vs 0.85 cm) and elevated triglycerides (1.09 cm vs 0.86 cm).
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