Key result
Higher perirenal fat thickness linked to ~2.8-fold higher risk of incident albuminuria in T2D.
Why the study?
Perirenal fat affects the kidney through physical structure and adipocytokines, but its relationship with the onset and progression of albuminuria in diabetes needed exploration.
Does higher perirenal fat thickness predict the onset and progression of albuminuria in patients with type 2 diabetes mellitus?
Cohort (n=959)
No
Does higher perirenal fat thickness predict the onset and progression of albuminuria in patients with type 2 diabetes mellitus?
Perirenal fat thickness measured by ultrasound is a feasible, noninvasive predictor for the development of diabetic kidney disease and onset of albuminuria.
Answers are grounded in this paper and cite their sources.
May support perirenal fat ultrasound for albuminuria risk stratification in type 2 diabetes; hypothesis-generating and requires prospective validation.
Background. Perirenal fat (PRF) has multiple effects on the kidney through its physical structure and adipocytokine-secreting ability. The present study explored the relationship between PRF thickness and the onset and progression of albuminuria in patients with diabetes. Methods. In the cross-sectional analysis, we screened 959 patients from 8764 subjects with type 2 diabetes mellitus (T2DM) who met the inclusion criteria and measured their perirenal fat thickness (PFT) using color Doppler ultrasound. A group of laboratory indexes were included in the analysis models. In a longitudinal study, a total of 218 patients with a baseline UACR <30 mg/g were included in the follow-up study. Results. In a cross-sectional analysis, patients with diabetes and higher PFT presented with higher albuminuria. Multiple logistic regression analysis indicated that PFT was an independent risk factor for the degree of albuminuria in patients with T2DM (odds ratio = 4.186, 95%CI: 2.290–7.653, <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>P</a:mi> </a:math> < 0.001). In a longitudinal study, 218 albuminuria-free patients with T2DM at the baseline were followed up for a mean of 12.3 months. Based on the cutoff value from the ROC diagnostic test in the cross-sectional study, patients were divided into two groups: higher PFT (H-PFT) and lower PFT (L-PFT). Kaplan–Meier survival curve analysis showed that H-PFT was associated with a higher incidence of albuminuria than L-PFT (log-rank test, χ2 = 4.522, <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:mi>P</c:mi> </c:math> = 0.033). Cox regression analysis showed that PFT was a risk factor for the earlier onset of albuminuria (hazard ratio 2.83, 95% CI: 1.34–4.88, <e:math xmlns:e="http://www.w3.org/1998/Math/MathML" id="M3"> <e:mi>P</e:mi> </e:math> < 0.001). Conclusions. PRF evaluated by color Doppler ultrasound is an easy and reliable tool for predicting the onset and progression of albuminuria in patients with T2DM.
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Hu et al. (2022) conducted a cohort in Type 2 Diabetes Mellitus (T2DM) with Diabetic Kidney Disease (n=959). Higher perirenal fat thickness (PFT) vs. Lower perirenal fat thickness was evaluated on Onset of albuminuria (HR 2.83, 95% CI 1.34-4.88, p=<0.001). Higher perirenal fat thickness was an independent risk factor for the earlier onset of albuminuria in patients with type 2 diabetes mellitus (HR 2.83, 95% CI 1.34-4.88, p<0.001).
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