Why the study?
Perirenal fat affects the kidney through physical structure and adipocytokines, but its relationship with the onset and progression of albuminuria in diabetes needed exploration.
Does higher perirenal fat thickness predict the onset and progression of albuminuria in patients with type 2 diabetes mellitus?
Population
959 patients with T2DM (218 albuminuria-free patients followed longitudinally)
Comparison
Higher vs lower perirenal fat thickness
Design
Cross-sectional and longitudinal observational study
Follow-up
Mean of 12.3 months
Key result
Higher perirenal fat thickness was significantly associated with an increased risk of earlier onset of albuminuria in patients with type 2 diabetes (HR 2.83; 95% CI 1.34-4.88; P<0.001).
Authors
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Perirenal fat thickness may aid albuminuria risk stratification in T2D; leaves open incremental value and requires prospective validation before practice change.
Observational (n=959)
Does higher perirenal fat thickness predict the onset and progression of albuminuria in patients with type 2 diabetes mellitus?
Hazard Ratio: 2.83 (95% CI 1.34–4.88)
p-value: p=<0.001
Perirenal fat thickness measured by ultrasound is an independent predictor of the onset and progression of albuminuria in patients with type 2 diabetes.
Hu et al. (2022) conducted an observational in Type 2 diabetes mellitus (n=959). Higher perirenal fat thickness (PFT) vs. Lower perirenal fat thickness was evaluated on Onset of albuminuria (HR 2.83, 95% CI 1.34-4.88, p=<0.001). Higher perirenal fat thickness was significantly associated with an increased risk of earlier onset of albuminuria in patients with type 2 diabetes (HR 2.83; 95% CI 1.34-4.88; P<0.001).