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June 22, 2021DiabetesOpen Access

Each SD increment in baseline PRFT was associated with a higher incidence of CKD (hazard ratio 1.67, 95% CI 1.04-2.68), with a higher predictive value (C-statistic 0.668) than TBF, SAT, and VAT.

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Why the study?

To investigate whether perirenal fat is an independent predictor for chronic kidney disease and compare it with total, subcutaneous, or visceral fat in patients with diabetes.

Does perirenal fat thickness predict the development of chronic kidney disease better than total, subcutaneous, or visceral fat in patients with type 2 diabetes?

Population

190 patients with T2DM without CKD at baseline

Comparison

Perirenal fat thickness vs total body fat, subcutaneous adipose tissue, and visceral adipose tissue

Design

Cross-sectional and longitudinal cohort study

Follow-up

2 years

Authors

XCXiangjun ChenXizang Minzu UniversityYMYun MaoThe Affiliated Yongchuan Hospital of Chongqing Medical UniversityJHJinbo HuChongqing University

Discussion

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Member takes

Overview

May inform CKD risk stratification in type 2 diabetes; leaves open whether perirenal fat thickness improves prediction beyond established markers in trials.

Structured PICO

Does perirenal fat thickness predict the development of chronic kidney disease better than total, subcutaneous, or visceral fat in patients with type 2 diabetes?

P
Population
190 patients with type 2 diabetes mellitus (T2DM) without chronic kidney disease (CKD) at baseline
I
Intervention
Higher perirenal fat thickness (PRFT) measured by computed tomography
C
Comparator
Total body fat (TBF), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) assessed by DEXA
O
Outcome
Incidence of chronic kidney disease (CKD)hard clinical

Perirenal fat thickness is an independent predictor of incident chronic kidney disease in patients with type 2 diabetes, outperforming total, subcutaneous, and visceral fat measurements.

Cite This Study

Chen et al. (2021) studied this question.

synapsesocial.com/papers/6a83beca47147a06038dd337https://doi.org/10.2337/db20-1031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Para-perirenal fat thickness is associated with reduced glomerular filtration rate regardless of other obesity-related indicators in patients with type 2 diabetes mellitus2023 · 17 citations
  2. 2The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease2022 · 11 citations
  3. 3Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease2019 · 76 citations
  4. 4Role of perirenal adiposity in renal dysfunction among CKD individuals with or without diabetes: a Japanese cross-sectional study2024 · 6 citations
  5. 5Perirenal fat thickness contributes to the estimated 10-year risk of cardiovascular disease and atherosclerotic cardiovascular disease in type 2 diabetes mellitus2024 · 16 citations