Key result
Perirenal fat thickness is significantly associated with chronic kidney disease (95% CI 0.48-0.65; p=0.00).
Why the study?
Previous studies have evaluated the impact of perirenal fat on CKD, but no systematic reviews and meta-analyses have investigated this association.
Is perirenal fat thickness associated with chronic kidney disease?
Meta-Analysis (n=2,576)
Is perirenal fat thickness associated with chronic kidney disease?
p-value: p=0.00
Perirenal fat thickness is significantly associated with chronic kidney disease, suggesting it may be a relevant indicator in diagnosing and treating CKD patients.
Perirenal fat thickness may aid CKD risk stratification; first meta-analysis confirms association but leaves causality and intervention effects open.
INTRODUCTION: Although previous studies have investigated the impact of perirenal fat on chronic kidney disease (CKD), there are yet no systematic reviews and meta-analyses to investigate the association between perirenal fat and CKD. METHODS: We searched six English electronic databases including PubMed, Scopus, Web of Science, Ovid, Embase, and the Cochrane Library to select clinical studies that reported the relationship between perirenal fat and CKD, and the search period ranged from the establishment of the database to September 10, 2024. Two researchers independently screened the studies and ultimately compared the literature. Stata (version 16 SE; College Station, TX, USA) software was used for statistical analysis. RESULTS: A total of eight articles that included 2,576 patients were included in this meta-analysis. The results showed a significant association between perirenal fat and CKD (95% CI: 0.48-0.65, p = 0.00), and no heterogeneity was detected between these two groups (I2 = 31.06%, p = 0.18). Subgroup analysis revealed that whether it is diabetic nephropathy, nephropathy caused by abnormal cardiac function, or primary CKD, perirenal fat is closely related to them. CONCLUSION: The results of this systematic review and meta-analysis showed that perirenal fat thickness is closely related to CKD. Clinicians should pay attention to relevant indicators when diagnosing and treating patients with CKD.
No takes yet. Share an insight, caveat, or question.
Kang et al. (2025) conducted a meta-analysis in Chronic kidney disease (CKD) (n=2,576). Perirenal fat was evaluated on Association between perirenal fat and CKD (95% CI 0.48-0.65, p=0.00). Perirenal fat thickness is significantly associated with chronic kidney disease (95% CI 0.48-0.65; p=0.00).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: