Why the study?
Does higher dose intravenous amiodarone reduce arrhythmia event rates in patients with refractory, life-threatening ventricular tachyarrhythmias compared to lower doses?
Population
342 patients with refractory, recurrent hemodynamically destabilizing ventricular tachycardia or ventricular…
Comparison
Intravenous amiodarone 500 mg or 1000 mg during… vs Intravenous amiodarone 125 mg during the first…
Design
RCT, randomized, double-blind
Follow-up
48 hours
Authors
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Supports higher-dose IV amiodarone for refractory VT/VF; confirms dose-dependent suppression in this RCT.
Does higher dose intravenous amiodarone reduce arrhythmia event rates in patients with refractory, life-threatening ventricular tachyarrhythmias compared to lower doses?
Intravenous amiodarone demonstrates a dose-dependent efficacy in suppressing recurrent, life-threatening ventricular tachyarrhythmias, with higher doses providing greater reduction in arrhythmic events.
Scheinman et al. (1995) studied this question.