Why the study?
Does eplerenone reduce sustained atrial tachyarrhythmia inducibility in a canine model of RVP-induced CHF?
Population
Canine model of rapid ventricular pacing (RVP)-induced congestive heart failure (CHF) and sham-operated dogs
Comparison
Eplerenone 50 mg/day oral for 5 weeks vs Oral placebo for 5 weeks
Design
Preclinical, assigned randomly
Follow-up
5 weeks
Authors
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Should not yet change AF/HF practice; leaves open translation of eplerenone effects from this canine RVP model.
Does eplerenone reduce sustained atrial tachyarrhythmia inducibility in a canine model of RVP-induced CHF?
Selective aldosterone blockade with eplerenone suppresses atrial tachyarrhythmia inducibility and attenuates LV diastolic remodeling in a canine model of pacing-induced heart failure.
Shroff et al. (2006) studied this question.
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