Key result
Rapid post-PCI ECG dynamics are linked to ~17% higher LVEF at 3 months versus slow dynamics.
Why the study?
Does rapid ECG stage dynamics predict improvement in myocardial perfusion and function in patients with TIMI-3 flow after primary angioplasty for acute MI?
Cohort (n=100)
Does rapid ECG stage dynamics predict improvement in myocardial perfusion and function in patients with TIMI-3 flow after primary angioplasty for acute MI?
Rapid ECG stage dynamics (≥2 stages per 2 days) after primary PCI with TIMI-3 flow for acute MI is associated with significant improvements in myocardial perfusion and function at 3 months.
BACKGROUND AND OBJECTIVE: Post-PCI TIMI flow grade 3 in infarct-related artery not always is associated with follow-up improvement in myocardial perfusion and function. We compared the improvement in myocardial perfusion and function in cases of rapid and slow electrocardiographic (ECG) stage dynamics between patients with TIMI-3 flow after primary angioplasty for acute myocardial infarction (MI). MATERIALS AND METHODS: Ten patients with post-PCI TIMI-3 flow were divided into group A (n=50, no rapid change of ECG stages) and group B (n=50, with a ≥2 ECG stages per 2 days change rate). RESULTS: There were no significant changes after 3 months in scintigraphic (ejection fraction 44.6±9.3% vs. 42.0±3.4%, P=0.4; perfusion deficit severity 3.0±0.7 vs. 2.3±0.8, P=0.1) and echocardiographic (dysfunction score 1.9±0.2 vs. 1.6±0.5, P=0.2) data in group A. Scintigraphic data improved (ejection fraction 34.6±3.9% vs. 52.0±7.3, P=0.03; perfusion deficit severity 2.8±0.6 vs. 1.5±0.8, P=0.03) and changes in echocardiographic data were of borderline significance (dysfunction score 1.8±0.2 vs. 1.4±0.4, P=0.06) in group B. CONCLUSIONS: There was not any change in myocardial perfusion and function in a case of slow change of ECG stages after reached post-PCI TIMI flow grade 3, while myocardial perfusion improved and function tended to improve in a case of the rate at least two ECG stages in 2 days after primary angioplasty for acute MI.
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Kalinauskienė et al. (2015) conducted a cohort in Acute myocardial infarction (n=100). Rapid change of ECG stages (≥2 stages per 2 days) vs. Slow change of ECG stages was evaluated on Improvement in myocardial perfusion and function. Rapid ECG stage dynamics (≥2 stages/2 days) after primary PCI for acute MI was associated with improved scintigraphic ejection fraction at 3 months (34.6% to 52.0%, P=0.03) compared to slow dynamics.
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