Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction
Key result
Higher exercise PCWP in HFpEF correlates with worse dyspnea, reduced exercise capacity, and impaired ventilation reserve.
- n=74
Population
74 subjects, including 50 with invasively-proven heart failure with preserved ejection fraction and 24…
Comparison
Cardiac catheterization at rest and during… vs Controls with non-cardiac causes of dyspnoea
Design
Cross-sectional
Authors
Discussion
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Implication
Elevated exercise PCWP may drive HFpEF symptoms; hypothesis-generating and requires prospective trials before guiding therapy.
Study Design
Type
Case-Control (n=74)
Structured PICO
P
Population
74 subjects, including 50 with invasively-proven heart failure with preserved ejection fraction (HFpEF) and 24 controls with non-cardiac causes of dyspnoea.
I
Intervention
Cardiac catheterization at rest and during exercise with simultaneous expired gas analysis
C
Comparator
Controls with non-cardiac causes of dyspnoea
O
Outcome
Relationships between simultaneously measured central haemodynamics, symptoms (Borg perceived dyspnoea scores), and lung ventilatory and gas exchange abnormalities during exercisesurrogate
This study provides the first evidence linking altered exercise haemodynamics, specifically elevated left ventricular filling pressures, to pulmonary abnormalities and symptoms of dyspnoea in patients with HFpEF.
Cite This Study
Obokata et al. (2018) conducted a case-control in Heart failure with preserved ejection fraction (HFpEF) (n=74). Exercise testing with simultaneous cardiac catheterization and expired gas analysis vs. Controls with non-cardiac causes of dyspnoea was evaluated on Relationships between central haemodynamics, symptoms, and lung ventilatory and gas exchange abnormalities during exercise. In patients with HFpEF, increasing exercise pulmonary capillary wedge pressure directly correlated with higher perceived dyspnoea scores, lower peak exercise capacity, and impaired ventilation reserve.