What does this research mean for the field?

The acid-labile (α) subunit of the IGF-binding protein complex is highly age- and growth hormone-dependent, and circulates in human serum with approximately two-thirds bound in the 150K complex and one-third uncomplexed. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1990The Journal of Clinical Endocrinology & Metabolism

Circulating Levels and Molecular Distribution of the Acid-Labile (α) Subunit of the High Molecular Weight Insulin-Like Growth Factor-Binding Protein Complex*

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Structured PICO

Population

170 children, 93 normal adults, 12 acromegalics, 10 GH-deficient subjects, and 18 third term pregnant women

Outcome

Serum alpha-subunit levelssurrogate

A newly developed RIA for the acid-labile subunit of the IGF-binding protein complex demonstrates age- and GH-dependent variations in serum levels.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May reflect GH axis activity; leaves open biomarker utility pending prospective validation.

Cite This Study

Robert C. Baxter (1990) studied this question.

synapsesocial.com/papers/6a06cee0964d5135c0d3d08b https://doi.org/10.1210/jcem-70-5-1347

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Circulating Levels and Molecular Distribution of the Acid-Labile (α) Subunit of the High Molecular Weight Insulin-Like Growth Factor-Binding Protein Complex*

Structured PICO

Discussion

Implication

Cite This Study

Circulating Levels and Molecular Distribution of the Acid-Labile (α) Subunit of the High Molecular Weight Insulin-Like Growth Factor-Binding Protein Complex*

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider