Key result
Rat acid-labile subunit (ALS) was successfully purified and demonstrated similar binding properties (association constant 2.3 nM-1), age dependence, and growth hormone dependence to human ALS.
Rat ALS shares similar binding properties, age dependence, and growth hormone dependence with human ALS, and a newly developed RIA will facilitate further studies in rats.
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Rat ALS purification enables rodent IGF studies; leaves open translation to human GH axis physiology.
Robert C. Baxter (1994) studied this question. Purification and characterization of rat ALS vs. Human ALS / Control rats was evaluated on Purification yield and binding properties of rat ALS. Rat acid-labile subunit (ALS) was successfully purified and demonstrated similar binding properties (association constant 2.3 nM-1), age dependence, and growth hormone dependence to human ALS.
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