Key result
Sequencing of 12 serotype-4 astroviruses from Japan identified two new subgroups with >93% intrasubgroup homology, which differed significantly (<50% homology) from other serotypes.
Population
12 serotype-4 astroviruses isolated in Japan
Comparison
Sequencing of the entire capsid regions vs Sequences of other astrovirus serotypes
Design
Other
Authors
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Astrovirus surveillance should incorporate serotype-4 diversity; leaves open effects on epidemiology and antigenicity.
Japanese serotype-4 astrovirus isolates form two distinct subgroups that are highly homologous internally but genetically distinct from other known serotypes.
Hachiya et al. (1999) studied Human Astrovirus Serotype 4 (n=12). Genetic sequencing of the capsid region vs. Other astrovirus serotypes (1, 2, 3, 5, 6, 7, and 8) was evaluated on Nucleic acid and deduced amino acid sequence homology. Sequencing of 12 serotype-4 astroviruses from Japan identified two new subgroups with >93% intrasubgroup homology, which differed significantly (<50% homology) from other serotypes.
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