Key result
Patients with neurocardiogenic syncope exhibited higher beta- and alpha-sensitivity and lower beta-activity and beta- and alpha-secretion compared to control subjects.
Why the study?
Does basic autonomic nervous function differ between patients with neurocardiogenic syncope and control subjects?
Case-Control
Does basic autonomic nervous function differ between patients with neurocardiogenic syncope and control subjects?
Patients with neurocardiogenic syncope exhibit altered autonomic function characterized by higher beta- and alpha-sensitivity and lower sympathetic secretion compared to controls.
Altered autonomic function may underlie neurocardiogenic syncope; hypothesis-generating and requires prospective validation before clinical adoption.
Basic autonomic nervous function was evaluated in patients with neurocardiogenic syncope (NCS). Atropine, isoproterenol, propranolol, phenylephrine, and phentolamine were administered successively, and parasympathetic nerve activity and beta- (and alpha-) activity, sensitivity, and secretion of the sympathetic nerve were determined in patients with NCS and control subjects. In patients with NCS, beta- and alpha- sensitivity were higher and beta-activity and beta- and alpha-secretion lower than in control subjects. In patients with NCS, the increased basic beta-sensitivity may contribute to induce strong cardiac contractions and augment ventricular mechanoreceptor response, and a compensatory state against diminished neuronal sympathetic activity is suggested by the increased alpha-sensitivity.
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Saito et al. (2007) conducted a case-control in Neurocardiogenic syncope. Pharmacological autonomic testing (atropine, isoproterenol, propranolol, phenylephrine, phentolamine) vs. Control subjects was evaluated on Parasympathetic nerve activity and beta- (and alpha-) activity, sensitivity, and secretion of the sympathetic nerve. Patients with neurocardiogenic syncope exhibited higher beta- and alpha-sensitivity and lower beta-activity and beta- and alpha-secretion compared to control subjects.
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