Key result
Maternal acetaminophen during pregnancy links to prenatal ductus arteriosus closure in 2 clinical cases.
Why the study?
Does paracetamol/acetaminophen use during pregnancy cause prenatal ductus arteriosus closure?
Case Report (n=2)
Does paracetamol/acetaminophen use during pregnancy cause prenatal ductus arteriosus closure?
Maternal use of paracetamol/acetaminophen during pregnancy, particularly after the sixth month, may cause premature closure of the fetal ductus arteriosus, leading to severe fetal or neonatal complications.
Answers are grounded in this paper and cite their sources.
May warrant caution with late-pregnancy paracetamol; case reports leave causal confirmation open for larger studies.
Paracetamol or acetaminophen (APAP) is commonly used as a first line treatment of pain and fever in pregnancy. In view of new evidence that reveals that APAP medication during pregnancy may be associated with impaired outcomes, safety of the use of APAP during pregnancy should be questioned. The causality between maternal APAP treatment and prenatal ductus arteriosus closure was qualified as certain by using the World Health Organization Uppsala Monitoring Center causality assessment system in a short series of 2 clinical cases. Because the fetal ductus arteriosus closure can lead to fetal loss or life-threatening cardiac failure in the newborn, the use of APAP, specifically after the sixth month of pregnancy, should be as limited as possible.
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Becquet et al. (2018) conducted a case report in Pregnancy (n=2). Paracetamol/Acetaminophen (APAP) was evaluated on Prenatal ductus arteriosus closure. Maternal paracetamol/acetaminophen treatment during pregnancy was identified as a certain cause of prenatal ductus arteriosus closure in a series of 2 clinical cases.
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