Key result
Maternal self-medication with paracetamol and polyphenol-rich foods in late pregnancy led to premature ductus arteriosus closure and severe cardiomyopathy in a term neonate.
Why the study?
Does maternal paracetamol and polyphenol consumption cause premature ductus arteriosus closure and cardiomyopathy in neonates?
Case Report (n=1)
Does maternal paracetamol and polyphenol consumption cause premature ductus arteriosus closure and cardiomyopathy in neonates?
Maternal use of paracetamol combined with polyphenol-rich foods in late pregnancy may lead to premature closure of the ductus arteriosus and severe neonatal cardiomyopathy.
Maternal paracetamol and polyphenol use in late pregnancy may warrant caution; this case report leaves a causal link to neonatal cardiomyopathy open.
Paracetamol (acetaminophen or N-acetyl-p-aminophenol) is considered a safe analgesic and antipyretic nonsteroidal antiinflammatory drug commonly used during pediatric ages and during pregnancy. We report on a term neonate with closed ductus arteriosus, severe cardiomyopathy, right ventricular dysfunction, and functional stenosis of pulmonary arteries at birth after maternal self-medication with paracetamol and consumption of polyphenol-rich foods in late pregnancy. This drug, especially when associated with other vasoconstrictors (such as polyphenols), interferes with prostaglandin metabolism, which seriously accentuates the intrauterine ductus arteriosus constriction and leads to pharmacologic adverse events. We suggest maternal educational programs to avoid risky self-medications and provide training for the best diets.
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Schierz et al. (2018) conducted a case report in Cardiomyopathy due to premature ductus arteriosus closure (n=1). Maternal paracetamol and polyphenol-rich food consumption was evaluated. Maternal self-medication with paracetamol and polyphenol-rich foods in late pregnancy led to premature ductus arteriosus closure and severe cardiomyopathy in a term neonate.
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