Key result
Higher baseline pulse pressure was independently associated with an increased risk of new-onset diabetes in high-risk hypertensive patients (HR 1.44 per 1 SD increase; 95% CI 1.15-1.79).
Why the study?
Does pulse pressure predict new-onset diabetes in high-risk hypertensive patients?
Population
2,685 high-risk Japanese hypertensive patients without diabetes at baseline
Design
Cohort
Follow-up
3.3 +/- 0.8 years
Authors
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Should not yet guide diabetes risk stratification by pulse pressure; leaves open whether arterial stiffness is causal or modifiable.
Cohort (n=2,685)
Does pulse pressure predict new-onset diabetes in high-risk hypertensive patients?
Effect estimate: HR 1.44 (95% CI 1.15-1.79)
Pulse pressure is an independent predictor of new-onset diabetes in high-risk hypertensive patients, suggesting a link between arterial stiffness and diabetes development.
Yasuno et al. (2010) conducted a cohort in High-risk hypertension without diabetes (n=2,685). Pulse pressure was evaluated on New-onset diabetes (HR 1.44, 95% CI 1.15-1.79). Higher baseline pulse pressure was independently associated with an increased risk of new-onset diabetes in high-risk hypertensive patients (HR 1.44 per 1 SD increase; 95% CI 1.15-1.79).
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