Key result
Taurine protects mice against cisplatin-induced cardiac damage by mitigating ROS production, inflammation, and ER stress.
Authors
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No change to clinical practice; leaves open taurine's role in human cardioprotection trials.
Chowdhury et al. (2016) studied Cisplatin-induced cardiotoxicity. Taurine vs. Cisplatin alone was evaluated on Cisplatin-mediated cardiac ER stress dependent apoptotic death and inflammation. Taurine administration protected mice against cisplatin-induced cardiac damage by mitigating reactive oxygen species production, inflammation, and endoplasmic reticulum stress responses.
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