Key result
Endothelin caused a 1.5- to 4.5-fold concentration-dependent increase in the release of atrial natriuretic factor from isolated rat right atria, which was significantly greater in hypertensive rats.
Why the study?
Does endothelin increase the release of atrial natriuretic factor in isolated atria from hypertensive rats compared to normotensive rats?
Does endothelin increase the release of atrial natriuretic factor in isolated atria from hypertensive rats compared to normotensive rats?
Effect estimate: 1.5-4.5-fold increase
Endothelin directly stimulates the release of atrial natriuretic factor from rat atria in vitro, with an accentuated response in hypertensive rats, suggesting a potential mechanism for its in vivo depressor effect.
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Does not support clinical translation; hypothesis-generating for endothelin-ANF interactions in hypertensive models.
Winquist et al. (1989) studied Hypertension. Endothelin vs. Wistar-Kyoto normotensive rats (WKY) was evaluated on Release of immunoreactive atrial natriuretic factor (irANF) (1.5-4.5-fold increase). Endothelin caused a 1.5- to 4.5-fold concentration-dependent increase in the release of atrial natriuretic factor from isolated rat right atria, which was significantly greater in hypertensive rats.
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