Why the study?
The intratubular renin-angiotensin system is thought to play an essential role in hypertensive renal disease, but information regarding sex-related differences in this system is limited.
Population
Sprague-Dawley rats
Comparison
Male vs female vs ovariectomized female 2K1C rats
Design
Preclinical animal study
Follow-up
3 or 5 wk
Key result
Female rats were protected from hypertensive renal and cardiac injury after renal artery clipping, associated with an increase in the intratubular nonclassic RAS and a decreased AT1/AT2 receptor ratio.
Authors
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Animal data suggest sex-specific protection in renovascular hypertension; leaves open clinical translation of nonclassic RAS modulation.
Female rats are protected from renovascular hypertension-induced injury via estrogen-mediated upregulation of the nonclassic intratubular renin-angiotensin system.
Lee et al. (2019) studied Renovascular hypertension. Female sex (estrogen presence) vs. Male rats and ovariectomized (OVX) female rats was evaluated on Intratubular renin-angiotensin system components and blood pressure. Female rats were protected from hypertensive renal and cardiac injury after renal artery clipping, associated with an increase in the intratubular nonclassic RAS and a decreased AT1/AT2 receptor ratio.
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