September 25, 2010AJP Heart and Circulatory Physiology
Erythropoietin enhances hydrogen peroxide-mediated dilatation of canine coronary collateral arterioles during myocardial ischemia in dogs in vivo
Key result
Erythropoietin significantly enhanced hydrogen peroxide-mediated dilatation of coronary collateral arterioles during myocardial ischemia in dogs in vivo, ameliorating oxidative stress and injury.
Why the study?
Does erythropoietin enhance hydrogen peroxide-mediated dilatation of coronary collateral arterioles during myocardial ischemia in a canine model?
Population
Canine model of left anterior descending coronary artery ischemia (90 min), n=40 (8 groups of n=5).
Comparison
Erythropoietin with or without various inhibitors. vs Control (ischemia without EPO).
Design
Preclinical
Follow-up
90 min
Authors
Discussion
Loading...
Member takes
Implication
May inform future cardioprotection research; leaves open translation from this canine model to human ischemia.
Structured PICO
Does erythropoietin enhance hydrogen peroxide-mediated dilatation of coronary collateral arterioles during myocardial ischemia in a canine model?
P
Population
Canine model of left anterior descending coronary artery ischemia (90 min), n=40 (8 groups of n=5).
I
Intervention
Erythropoietin (EPO) with or without various inhibitors (catalase, l-NMMA, iberiotoxin, apamin+charybdotoxin, wortmannin).
C
Comparator
Control (ischemia without EPO).
O
Outcome
Vasodilatation of subepicardial native collateral small arteries (≥ 100 μm) and arterioles (<100 μm).surrogate
Erythropoietin enhances hydrogen peroxide-mediated dilatation of coronary collateral arterioles and reduces myocardial injury during ischemia in a canine model.
Cite This Study
Yada et al. (2010) studied Myocardial ischemia (n=40). Erythropoietin (EPO) vs. Control and various inhibitors (catalase, l-NMMA, iberiotoxin, apamin, charybdotoxin, wortmannin) was evaluated on Vasodilatation of coronary collateral arterioles and small arteries. Erythropoietin significantly enhanced hydrogen peroxide-mediated dilatation of coronary collateral arterioles during myocardial ischemia in dogs in vivo, ameliorating oxidative stress and injury.