Why the study?
Does intensive lowering of blood pressure and addition of acetylsalicylic acid reduce cardiovascular events in hypertensive patients with reduced renal function?
Population
Hypertensive participants of the Hypertension Optimal Treatment Study, including patients with reduced renal…
Comparison
Intensive lowering of blood pressure to… vs Different diastolic BP targets
Design
RCT, Randomized to different diastolic BP targets
Follow-up
3.8-yr
Authors
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Intensive BP lowering yields no CV event reduction in mild renal insufficiency; extends HOT evidence supporting acetylsalicylic acid addition.
Does intensive lowering of blood pressure and addition of acetylsalicylic acid reduce cardiovascular events in hypertensive patients with reduced renal function?
In hypertensive patients with mild renal insufficiency, intensive BP lowering does not significantly reduce major cardiovascular events compared to standard targets, but adding acetylsalicylic acid may offer additional benefit.
Ruilope et al. (2001) studied this question.
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