Key result
Ingramon-depot linked to less severe myocardial necrosis in obese db/db mice.
Why the study?
To evaluate structural and functional features of the myocardium in db/db mice and assess the impact of prolonged depot Ingramon on the left ventricular myocardium.
Does prolonged administration of Ingramon-depot improve structural and functional features of the myocardium in obese db/db mice?
Population
C5bl/KsJ-db/db and C57bl/6 mice
Comparison
Subcutaneous Ingramon-depot vs control
Design
Preclinical animal study
Authors
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Hypothesis-generating for Ingramon-depot effects in diabetic cardiomyopathy models; human trials needed before any clinical consideration.
Does prolonged administration of Ingramon-depot improve structural and functional features of the myocardium in obese db/db mice?
In a mouse model of metabolic syndrome and early HFpEF, prolonged administration of Ingramon-depot reduced the severity of myocardial necrotic changes.
Radyukhina et al. (2026) studied this question. Ingramon-depot administration was associated with less severe necrotic changes in the myocardium of obese db/db mice.
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