Key result
Balloon aortic valvuloplasty in severe aortic stenosis patients with LVEF <20% had 0% procedural mortality, and 47% of patients demonstrated an improvement in LVEF to ≥20%.
Why the study?
Does balloon aortic valvuloplasty improve LVEF and survival in high-risk aortic stenosis patients with LVEF <20%?
Cohort (n=16)
Does balloon aortic valvuloplasty improve LVEF and survival in high-risk aortic stenosis patients with LVEF <20%?
Balloon aortic valvuloplasty can safely improve LVEF to ≥20% in roughly half of high-risk severe aortic stenosis patients with baseline LVEF <20%, though long-term survival remains poor.
OBJECTIVES: To determine outcomes following balloon aortic valvuloplasty (BAV) in aortic stenosis (AS) patients with a left ventricular ejection fraction (LVEF) <20%. BACKGROUND: Severe AS patients with a LVEF <20% are excluded from United States (U.S.) transcatheter aortic valve replacement (TAVR) trials and often surgical aortic valve replacement (AVR). The role for BAV to enhance LVEF is unclear. METHODS: Our BAV database of 270 consecutive patients extending from 2005 through 2010 was queried for a preoperative LVEF <20%. Demographics, echocardiograms, procedural technique, and outcomes were analyzed. Pre- and postoperative echocardiograms were used to determine improvement in aortic valve area (AVA) and LVEF. RESULTS: Sixteen patients were identified with a median age of 82 years. The composite Society of Thoracic Surgeons' (STS) mortality risk was 16.4%. The median preoperative AVA and LVEF were 0.60 cm(2) and 16%, respectively, and postoperative AVA and LVEF were 0.77 cm(2) and LVEF 19%, respectively. About 15 of the 16 patients had postoperative echocardiograms available for comparison. And 7 of these 15 (47%) demonstrated improvement in LVEF to ≥20% (median LVEF 25%). The absence of coronary disease and improvement in AVA of ≥0.2 cm(2) was associated with postoperative LVEF of ≥20%. Procedural mortality was 0%. The 30-day, 6-month, and 1-year survival was 69%, 56%, and 29%. STS's mortality risk score ≥15% was associated with short-term mortality. CONCLUSION: With appropriate technique, BAV can be reasonably safe in patients with LVEF <20%. Roughly half of these patients demonstrated improvement in LVEF to ≥20%.
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Pedersen et al. (2013) conducted a cohort in Severe aortic stenosis with LVEF <20% (n=16). Balloon aortic valvuloplasty (BAV) was evaluated on Improvement in LVEF to ≥20%. Balloon aortic valvuloplasty in severe aortic stenosis patients with LVEF <20% had 0% procedural mortality, and 47% of patients demonstrated an improvement in LVEF to ≥20%.
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