Key result
A small fraction of mouse brain macrophages grown in vitro can be efficiently infected with Theiler's virus, leading to viral replication and continuous infectivity without significant cytolytic effect.
Theiler's virus can infect and replicate in a small fraction of mouse brain macrophages in vitro without significant cytolytic effect, providing insight into viral persistence in this multiple sclerosis model.
Hypothesis-generating for macrophage reservoirs in MS models; leaves open in vivo and human relevance.
Infection of the mouse with Theiler's virus is one of the best animal models for the study of multiple sclerosis, a chronic demyelinating disease of the human central nervous system. The identification of the virus target cell(s) is fundamental to an understanding of the viral persistence as well as the inflammation and demyelination observed in the chronic phase of the disease. This paper reports that a small fraction of brain macrophages grown in vitro can be efficiently infected with Theiler's virus without significant cytolytic effect. Viral replication as well as continuous production of infectivity were observed in these cultures.
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Lévy et al. (1992) studied Theiler's virus infection (multiple sclerosis model). Theiler's virus infection in vitro was evaluated on Viral replication and infectivity. A small fraction of mouse brain macrophages grown in vitro can be efficiently infected with Theiler's virus, leading to viral replication and continuous infectivity without significant cytolytic effect.
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