Key result
Depletion of blood-borne macrophages using mannosylated liposomes prevented viral persistence and demyelination in mice infected with Theiler's virus.
Population
Mice infected with Theiler's virus (murine picornavirus)
Design
Preclinical
Follow-up
up to at least 21 days postinoculation
Authors
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No immediate clinical implications for human demyelinating disease; leaves open further mapping of viral tropism in this model.
Depletion of blood-borne macrophages prevents viral persistence and demyelination in a murine model of Theiler's virus infection.
Rossi et al. (1997) studied Theiler's virus infection. Depletion of blood-borne macrophages with mannosylated liposomes containing dichloromethylene diphosphonate was evaluated on Viral persistence, mononuclear cell infiltration, and demyelination. Depletion of blood-borne macrophages using mannosylated liposomes prevented viral persistence and demyelination in mice infected with Theiler's virus.
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