Host cell factors play a key role in the mechanism of demyelination and the persistence of Theiler's virus in the nervous system.
Animal model data on Theiler's virus tropism warrant caution before clinical translation; leaves open host cell contributions to human demyelination.
The mechanisms of persistence and of demyelination in Theiler's virus (TV)-induced chronic neurologic disease (a murine model for multiple sclerosis) are, as yet, disputed. We investigated the tropism and persistence of TV in brain cell culture to better understand the pathogenesis of this disease. Using anti-genic markers to identify specific cells in culture, we have demonstrated that TV infects, lytically, neurons and oligodendrocytes and persistently astrocytes and macrophages. These results suggest that host cell factors play a key role in the mechanism of demyelination and the persistence of TV in the nervous system.
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Graves et al. (1986) studied this question.
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