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May 20, 2026American Journal of Respiratory and Critical Care Medicine

A56-10 Effectiveness of Cardiac Contractility Modulation Device in Management of Chronic Heart Failure

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Key result

CCM linked to ~37% lower six-year mortality versus no device in chronic HF.

  • RR 0.63
  • 95% CI 0.43-0.92
  • n=736

Why the study?

Data are limited regarding the effect of cardiac contractility modulation on long-term outcomes like mortality and hospitalization rates in chronic heart failure.

Does cardiac contractility modulation device placement reduce mortality in patients with chronic heart failure?

Comparison

CCM device placement vs without CCM device

Design

Retrospective propensity score-matched cohort study

Follow-up

6 years

Authors

SKS KhadkaUPMC Central PaJFJ FanizzaDrexel UniversityBBB BhandariWestern Maryland Health System

Discussion

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Implication

CCM was associated with lower mortality; hypothesis-generating and should not yet change practice without randomized confirmation.

Key Points

  • This study aims to evaluate the efficacy and safety of cardiac contractility modulation devices in patients with chronic heart failure.
  • Retrospective cohort study from the TriNetX Nationwide deidentified database.
  • Propensity score matching was used to compare outcomes between 368 patients with and without CCM devices.
  • Data collection from January 1, 2019 to January 1, 2025.
  • CCM patients had an 11.68% rate of ED visits in 1 month compared to 5.43% in non-CCM patients (OR 2.3, 95% CI 1.36-3.99).
  • 6-year follow-up revealed decreased mortality in CCM patients (15.47%) versus non-CCM (20.90%) (RR 0.63, 95% CI: 0.43-0.92).
  • New chronic kidney disease developed in 0.75% of CCM patients compared to non-CCM.

Study Design

Type

Cohort (n=736)

Multicenter

Yes

Structured PICO

Does cardiac contractility modulation device placement reduce mortality in patients with chronic heart failure?

P
Population
736 patients with chronic heart failure (368 per group after propensity matching), mean age 66.7 years, 51.50% white, 16.71% African American, 4.90% Hispanic.
I
Intervention
Cardiac contractility modulation (CCM) device placement
C
Comparator
No CCM device placement
O
Outcome
All-cause mortality at 6 yearshard clinical

Main Result

Effect estimate: RR 0.63 (95% CI 0.43-0.92)

Absolute Event Rate: 15.47% vs 20.9%

Cardiac contractility modulation device placement is associated with significantly decreased long-term mortality at 6 years compared to no CCM in patients with chronic heart failure.

Cite This Study

Khadka et al. (2026) conducted a cohort in Chronic heart failure (n=736). Cardiac contractility modulation (CCM) device vs. No CCM device was evaluated on All-cause mortality at 6 years (RR 0.63, 95% CI 0.43-0.92). Cardiac contractility modulation was associated with lower 6-year mortality compared to no device in chronic heart failure (15.47% vs 20.90%; RR 0.63, 95% CI 0.43-0.92).

synapsesocial.com/papers/6a0d4fbff03e14405aa9b1cahttps://doi.org/10.1093/ajrccm/aamag162.1330

Topics

Heart failureHFrEF treatmentHFpEF management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effectiveness of cardiac contractility modulation: results of two-year follow-up2024
  2. 2Clinical effects of long-term cardiac contractility modulation (CCM) in subjects with heart failure caused by left ventricular systolic dysfunction2017 · 44 citations
  3. 3QUALITY OF LIFE IMPROVEMENT AND REDUCTION IN HOSPITALIZATIONS IN PATIENTS WITH HEART FAILURE UNDERGOING CARDIAC CONTRACTILITY MODULATION (CCM) THERAPY: A SINGLE–CENTER EXPERIENCE2026
  4. 4Outcomes of Cardiac Contractility Modulation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials2019 · 24 citations
  5. 5USE OF CARDIAC CONTRACTILITY MODULATION: OUR EXPERIENCE2024